[Amazon] Do I need to add a Creation Profile?
Creation Profiles hold product information like marketplace category and item specifics (materials, country of origin, etc.), so adding a profile is needed only if a new listing has to be created on the marketplace. If an item doesn't have a product page yet, the marketplace needs full details about it.
When sending products to Amazon, it is likely that the product page already exists on the marketplace. If you are not sure, send the item without a Creation Profile first and check the results.
Send Shopify products to Amazon
When linking the products through the Inventory tab in Salestio, Creation Profiles can be skipped.